Prognostic Association of C-Erbb-2 Oncogene Amplification and Protein Overexpression in Human Breast Cancer Using Archival Tissues a Comparative Study
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولAmplification of c-erbB-2 and aggressive human breast tumors?
well as allelic deletions ofgenes on chromosomes 11 or 13 (9, 10). The frequency and level of amplification of c-myc and c-erbB-2 proto-oncogenes vary between different groups of patients studied by different laboratories. Amplification of c-erbB-2 was reported in 10, 16, 18, and 40% of breast tumors from different groups of patients (2, 5-8). In one study this proto-oncogene was suggested as a...
متن کاملAssociation of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.
Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplification was more common in breast tumors of advanced stage, and in tumors which had metastasized ...
متن کاملExpression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.
Sections of formalin-fixed, paraffin-embedded tissue from 185 primary breast carcinomas were stained immunohistochemically using a polyclonal antibody against the c-erbB-2 oncoprotein. Positive staining, which is known to correlate with gene amplification, was associated with earlier relapse, shorter postrelapse survival, and shorter overall survival. Lymph node, epidermal growth factor recepto...
متن کاملPrognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer.
Using the 21N polyclonal antibody, we immunohistochemically stained 314 primary breast carcinomas to identify those tumors overexpressing the c-erbB-2 oncoprotein and to ascertain the prognostic significance of this expression on disease-free and overall survival. Positive membrane staining was present in 52 (17%) of these carcinomas of which 7 (13%) were ductal carcinomas in situ. There was no...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 1994
ISSN: 0284-186X,1651-226X
DOI: 10.3109/02841869409083924